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Lenvat 4mg - Lenvatinib Capsules

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Lenvat 4mg - Lenvatinib Capsules

Lenvat 4mg is an oral anticancer medication containing Lenvatinib, a multi-kinase inhibitor used to treat certain types of thyroid cancer, renal cell carcinoma, and liver cancer. It helps slow or stop the growth of cancer cells by blocking proteins responsible for tumor development.

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Description Product Details
General Information:
Generic Name: Lenvatinib
Brand Name: Lenvat
Packing: Bottle or strip (typically 30 capsules per pack)
Strength: 4 mg per capsule
Manufacturer: Natco Pharma Ltd.
Form: Oral Capsules
Category: Antineoplastic, Tyrosine Kinase Inhibitor (TKI), Targeted Therapy
Product Intro:
Lenvat 4mg is a targeted therapy capsule used in the treatment of several cancers, including thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma. It contains Lenvatinib, a potent multi-kinase inhibitor that disrupts cancer cell growth and angiogenesis (blood vessel formation), offering a therapeutic advantage in advanced cancers. This formulation is especially beneficial in patients not responding to traditional therapies.
Uses:
  1. Differentiated thyroid cancer (DTC) resistant to radioactive iodine
  2. Advanced renal cell carcinoma (RCC) (in combination with everolimus)
  3. Unresectable hepatocellular carcinoma (HCC)
  4. Endometrial cancer (in combination with pembrolizumab – under specific guidelines)
  5. Investigated in other solid tumors in clinical trials
  6. Used as second-line therapy in some cancers unresponsive to first-line treatment
Storage Instructions:
  1. Store at 20°C to 25°C (68°F to 77°F)
  2. Protect from light and moisture
  3. Keep in the original container, tightly closed
  4. Keep away from children and pets
How it Works (Mechanism of Action):
Lenvatinib works by inhibiting multiple tyrosine kinases, including VEGFR, FGFR, PDGFR, RET, and KIT.
These enzymes are involved in:
  1. Tumor angiogenesis (formation of new blood vessels)
  2. Cancer cell proliferation
  3. Tumor growth and spread
    By blocking these pathways, Lenvatinib starves the tumor of nutrients and oxygen needed for its growth.
Side Effects:
Common Side Effects:
  1. High blood pressure (hypertension)
  2. Fatigue
  3. Diarrhea
  4. Decreased appetite
  5. Nausea and vomiting
  6. Weight loss
  7. Joint or muscle pain
  8. Swelling in hands or feet
Serious Side Effects:
  1. Heart problems (heart failure, QT prolongation)
  2. Kidney or liver dysfunction
  3. Severe bleeding
  4. Protein in the urine (proteinuria)
  5. Gastrointestinal perforation (rare but serious)
Dosage (Typical Recommended Dose):
  1. Usual starting dose:
    1. 8 mg once daily (for patients <60 kg body weight)
    2. 12 mg once daily (for patients ≥60 kg)
  2. Dosage can vary based on cancer type and patient condition
  3. Lenvat 4mg may be used alone or with Lenvat 10mg capsules to adjust dose
  4. Always take as prescribed by your oncologist
Method of Administration:
  1. Take orally, once daily, at the same time each day
  2. Can be taken with or without food
  3. Swallow capsules whole with water
  4. Do not crush or chew the capsules
Precautions:
  1. Monitor blood pressure regularly
  2. Inform doctor if you have heart, liver, or kidney conditions
  3. Not recommended during pregnancy or breastfeeding
  4. Use effective contraception during treatment and for at least 1 month after
  5. Avoid activities requiring alertness if you feel dizzy or weak
Drug Interactions:
  1. Avoid with CYP3A inhibitors/inducers (e.g., ketoconazole, rifampin)
  2. May interact with antihypertensive drugs
  3. Monitor if used with anticoagulants (e.g., warfarin)
  4. Herbal products like St. John’s Wort may reduce effectiveness
Allergies:
  1. Do not use if allergic to Lenvatinib or its excipients
  2. Watch for allergic reactions: rash, itching, difficulty breathing, swelling
Overdose Information:
  1. Symptoms: Severe hypertension, nausea, vomiting, cardiac effects
  2. In case of overdose, seek emergency medical attention
  3. No specific antidote; treatment is supportive and symptomatic
Missed Dose Instructions:
  1. If missed and less than 12 hours have passed: take it as soon as you remember
  2. If more than 12 hours: skip the dose, take the next one at the regular time
  3. Do not double dose to make up for a missed one
Additional Notes:
  1. Regular blood tests and scans are necessary to monitor progress and side effects
  2. Maintain hydration and a balanced diet
  3. Report unusual bleeding, chest pain, or vision changes immediately
  4. May be adjusted or paused during surgery or serious infection
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