Azadine 100mg - Azacitidine For Injuction

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1. Myelodysplastic Syndromes (MDS) – A group of blood disorders where the bone marrow does not produce enough healthy blood cells.
2. Acute Myeloid Leukemia (AML) – A type of cancer affecting white blood cells.
3. Chronic Myelomonocytic Leukemia (CMML) – A rare blood cancer involving abnormal white blood cell production.
4. Pre-leukemic Conditions – Helps prevent the progression of MDS to leukemia.
5. Bone Marrow Disorders – Used to improve bone marrow function in patients with hematologic malignancies.

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1. Azacitidine is a DNA methyltransferase inhibitor, meaning it prevents the abnormal methylation of DNA in cancer cells.
2. By stopping this methylation, tumor-suppressing genes become active again, leading to normal cell function and preventing uncontrolled cancer growth.
3. Additionally, it incorporates into RNA, interfering with protein synthesis in abnormal cells and inducing apoptosis (programmed cell death).

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1. Standard dose: 75 mg/m² body surface area (BSA) per day for 7 consecutive days, repeated every 28 days.
2. The dose may be adjusted based on patient response and tolerance.

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1. Given as an injection (subcutaneous or IV infusion).
2. Administered once daily for 7 days in each treatment cycle.
3. Treatment cycles are usually repeated every 4 weeks.
4. Must be administered by a healthcare professional—do not self-administer.

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1. Nausea and vomiting
2. Fatigue and weakness
3. Fever and chills
4. Injection site reactions (redness, pain, swelling)
5. Low blood cell counts (anemia, leukopenia, thrombocytopenia)

1. Severe bone marrow suppression (increased risk of infections and bleeding)
2. Kidney damage – Signs include decreased urine output and swelling
3. Liver toxicity – Yellowing of the skin/eyes, dark urine
4. Severe allergic reactions – Rash, difficulty breathing, swelling of the face
5. Heart problems – Irregular heartbeat, chest pain

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Precautions Before Taking Azadine 100mg

1. Bone Marrow Suppression: Can cause dangerously low blood cell counts.
2. Infections: Increased risk of bacterial, viral, or fungal infections.
3. Liver & Kidney Function: Regular monitoring is required.
4. Pregnancy & Breastfeeding: Not recommended—may harm the baby.
5. Bleeding Disorders: Avoid if you have uncontrolled bleeding issues.

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1. Live vaccines – Avoid receiving live vaccines while on treatment.
2. Immunosuppressants (e.g., Cyclosporine, Tacrolimus) – Can increase the risk of infections.
3. Blood thinners (Warfarin, Aspirin) – May increase bleeding risk.
4. Nephrotoxic drugs (Cisplatin, Amphotericin B) – May worsen kidney damage.

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1. Do not take Azadine if allergic to Azacitidine or its ingredients.
2. Signs of an allergic reaction:
   1. Swelling of face, lips, or throat
   2. Difficulty breathing
   3. Severe rash or itching
   4. Dizziness or fainting

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1. Store at 2°C - 8°C (Refrigerated).
2. Do not freeze.
3. Keep away from light and moisture.
4. Use reconstituted solution within the recommended time.

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1. Severe nausea and vomiting
2. Profound bone marrow suppression (high risk of infections and bleeding)
3. Kidney and liver failure

1. Seek immediate medical attention.
2. Supportive care and hospitalization may be required.

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1. If a dose is missed, consult your doctor immediately.
2. Do not double the dose to make up for a missed injection.
3. Treatment schedules should be strictly followed for best results.